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It will come down to developing a strategy, then choosing what we think are the right targets, designing stable molecules, running the studies, and having the discipline to stop if its not working

GLP-1 RAs offer improved glycaemia, weight loss and cardiovascular benefits in those for whom they are recommended by the guidelines, so it is important that we facilitate their initiation and continuation in as many appropriate people as possible

When following a weight loss plan supported by GLP-1 medications, its easy to feel unsure about what foods will complement your progress

While gastrointestinal side effects are well-documented, some patients report skin-related concerns, including sensitive skin

In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

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