CYC-116 0-IN-1 A novel small-molecule inhibitor of

A novel small-molecule inhibitor of NF-kappaB signaling

CAS Number: 54739-18-3

SAR439859 shows promising antitumor activity in breast cancer mice xenograft models

Hesperetin suppresses NF-κB activation and reduces cholesterol biosynthesis

612847-09-3

CYC-116 0-IN-1 A novel small-molecule inhibitor ofCYC116 is an orally bioavailable small molecule multi kinase inhibitor with antineoplastic activity. Aurora kinase VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine threonine protein kinases that are only expressed in actively dividing cells and are critical in