Vinflunine tartrate Size:Solid 10 mg 1056901-62-2

1056901-62-2

PF-04457845

Transforming growth factor beta receptor I inhibitor sensitizes drug-resistant pancreatic cancer cells to gemcitabine

InChiKey: XYYAFLHHHZVPRN-JSGCOSHPSA-N

CID53347902

Vinflunine tartrate Size:Solid 10 mg 1056901-62-2Vinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.