AEE788 igomycin A InChi: InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5

InChi: InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5

Formula: C34H50N4O9S

The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

demonstrating potent antagonist activity

Wardlaw AJ

AEE788 igomycin A InChi: InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5AEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for