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NVP-BKM120 Hydrochloride - CAS# 1312445-63-8 locaine Hydrochloride with an IC50~19 nM

NVP-BKM120 Hydrochloride - CAS# 1312445-63-8 locaine Hydrochloride with an IC50~19 nM

Name: NVP-BKM120 Hydrochloride - CAS# 1312445-63-8 locaine Hydrochloride with an IC50~19 nM
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SKU: 92681013071
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SKU: 92681013071

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NVP-BKM120 Hydrochloride - CAS# 1312445-63-8 locaine Hydrochloride with an IC50~19 nMBuparlisib, also known as BKM120, is an orally bioavailable specific oral inhibitor of the pan class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K AKT kinase (or protein kinase B) signaling pathway in an ATP competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol 3,4,5 trisphosphate

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Description

with an IC50~19 nM

3-thiazolidine-3-carbonyl)pyrrolidin-3-yl]piperazine

Epub 2015 Apr 16

C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15

InChi: InChI=1S/C13H12N2O2

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