HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 size:2mg solid Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=O

Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=O

15(1):39-48

MDL29951 promotes Ca2+ signaling responses and inhibition of cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells during the period of peak GPR17 abundance

Doronina SO

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04

HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 size:2mg solid Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=OHG 10 102 01, CAS No. 1351758 81 0, is a brain penetrant, potent and selective inhibitor of wild type LRRK2 and the G2019S mutant (IC50 for LRRK2 wild type ~20. 3 nM and LRRK2 [G2019S] ~3. 2 nM). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild type LRRK2 and G2019S mutant at a concentration of 0. 10. 3 M in cells. HG 10 102 01 is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse