GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 JNJ-42041935 was used at 10

JNJ-42041935 was used at 10 µM final concentration in vitro and in cellular assays

JNJ-42041935 was dosed to mice orally at 100 µM/kg once per day

2007 May 1

Molecular Weight: 344

K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24

GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 60306 JNJ-42041935 was used at 10GSK2879552 dihydrochloride, CAS No. 1902123 72 1, is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO A B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions