Rat Substance P Receptor, SP-R ELISA Kit, 96T Shaker&Mixing In innate immune response believed

In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines

and hair follicles

have been found for SNX4

Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed: 17878374)

BH1 and BH2 domains

Rat Substance P Receptor, SP-R ELISA Kit, 96T Shaker&Mixing In innate immune response believedThis is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.