AT13148 - CAS# 1056901-62-2 60075 such as NODI and NOD2

such as NODI and NOD2

InChiKey: UHDOJINBFLDQJM-UHFFFAOYSA-N

PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer

Smiles: CN1N=CC(Cl)=C1C1C=C(SC=1Cl)C(=O)N[C@H](CN)CC1=CC(F)=CC=C1

irreversible and selective PPARgamma antagonist

AT13148 - CAS# 1056901-62-2 60075 such as NODI and NOD2AT13148, CAS No. 1056901 62 2, is a novel oral multi AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high throughput X ray crystallography and fragment based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK