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Further study of the effect of GLP-1 on thyroid follicular cells and longitudinal observation of the association of long-term GLP-1R activation with PTC is needed to clarify the meaning of GLP-1R expression in PTC and the long-term effects of incretin-based therapy on the thyroid

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Thyroid function, insulin resistance, cortisol levels, and baseline body composition play important roles in early progress

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Abbreviations LC: L-carnitine TC: Total carnitine TMAO: Trimethylamine-N-oxide CHO: Carbohydrates IGF-1: Insulin-like growth factor-1 PI3K: Phosphoinositide-3-kinase Akt: Protein kinase B mTOR: Mammalian target of rapamycin S6K: S6 kinase 4E-BP: 4E-binding protein FoxO: Forkhead box O MuRF-1: Muscle-specific RING finger-1 atrogin-1: Muscle atrophy F-box mRNA: Messenger RNA BMI: Body mass index ROS: Reactive oxygen species References Bremer J