NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 The corresponding cAC10-L4-MMAF4 ADC was
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NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 The corresponding cAC10-L4-MMAF4 ADC wasNMS 873, CAS NO. 1418013 75 8, is a potent and specific small molecule allosteric inhibitor of the ATPase VCP p97 (IC50 ~0. 03 M), identified by a high throughput screening. It is very selective (IC50 >10 M) against all of the AAA ATPases, HSP90 or the 53 kinases tested. Using photo affinity labeling, structural analysis and mutagenesis, the binding site of NMS 873 was found to be a region spanning the D1 and D2 domains of adjacent protomers
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