AMG 837 Sodium Salt Catalog No.:M8603-10 PubMed Central PMCID: PMC3706837
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AMG 837 Sodium Salt Catalog No.:M8603-10 PubMed Central PMCID: PMC3706837AMG 837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following
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