Epinastine 0119 Crew et al (2018) Identification

Crew et al (2018) Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1

InChi: InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5

resulting in its trafficking through HDAC6 to perinuclear aggresomes without cytokine stimulation or SOCS-1 induction

16)12-4-5-14(18)17-13(12)7-10/h3-6

14(2):e0211916

Epinastine 0119 Crew et al (2018) IdentificationEpinastine is a second generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood brain barrier. Product information CAS Number: 80012 43 7 Molecular Weight: 249. 31 Formula: C16H15N3 Synonym: Elestat WAL801 Chemical Name: 2,4 diazatetracyclo[12. 4. 0. 0,. 0,]octadeca 1(18),3,7,9,11,14,16 heptaen 3 amine Smiles: