GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S is an allosteric inhibitor of

is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM)

CAS Number: 955365-80-7

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1

Zarybnicka L

InChi: InChI=1S/C18H13F3N4O2/c19-18(20

GSK591 (EPZ015866) - PRMT5 Inhibitor. CAS# 1616391-87-7 Catalog No.:M60321-10S is an allosteric inhibitor ofGSK591, also known as EPZ015866 and GSK3203591, CAS No. 1616391 87 7, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5 MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z 138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. Product information CAS