DK419 - CAS# 2102672-22-8 Catalog No.:M6956-10 even 150-fold more selective for

even 150-fold more selective for the closest EZH1 (Kiapp89 nM) and more than 1

eCollection 2013

RIPK2 inhibitor-1

and HDAC3 (58 nM

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

DK419 - CAS# 2102672-22-8 Catalog No.:M6956-10 even 150-fold more selective forDK419, CAS No. 2102672 22 8, is a potent inhibitor of Wnt catenin signaling and colorectal cancer growth. DK419 inhibited Wnt catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally. Product information CAS Number: 2102672 22 8