WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 Epub 2017 Nov 3

Epub 2017 Nov 3

Oral dosing of GNF7156 in diabetic mice induces β-cell proliferation

colon weight per unit length in the control group is more than twice that in the normal group

InChi: InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H

Pre-treatment with 1 μM inhibits migration to a greater extent in the non-gradient assay than in the gradient assay

WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 Epub 2017 Nov 3WP1130 (Degrasyn), CAS No. 856243 80 6, is a cell permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs). At 5 M it directly inhibits DUB activity of USP9x, USP5, USP14, UCH L1, and UCH37, but not UCH L3, resulting in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL 1 and p53. WP1130 suppresses Bcr Abl, JAK2 transducer (without affecting 20S proteasome) and activator of transcription