CEP-37440 nalog-1 Inhibition was observed at heteromeric
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CEP-37440 nalog-1 Inhibition was observed at heteromericCEP 37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK FAK inhibitor CEP 37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK and FAK mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK and FAK
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