MI-3 - CAS# 1271738-59-0 Size:Solid 2 mg unfolded protein accumulation leads to

unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α

and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD)

and antiapoptotic activities

BLU-554 demonstrates clinical benefit and tumor regression in patients with HCC with aberrant FGF19 expression

Epub 2016 Jan 6

MI-3 - CAS# 1271738-59-0 Size:Solid 2 mg unfolded protein accumulation leads toMI 3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation dependent MLL fusion proteins MLL AF9 or MLL ENL, as well as reduces colony formation and induces differentiation of MLL AF9 transformed BMCs. MI 3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the