BLU-554 - CAS# 1707289-21-1. CAS# 1707289-21-1 284 PubMed PMID: 22737721

PubMed PMID: 22737721

Smiles: COC(=O)[C@H]1CC2=C(NC3=CC=CC=C32)[C@H](C2C=CC(=CC=2)C(=O)OC)N1C(=O)CCl

dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors

2015 Jan 21

It can cause a dramatic reduction of the intracellular Notch level and lead to significantly decreased expression of the Notch transcriptional target genes

BLU-554 - CAS# 1707289-21-1. CAS# 1707289-21-1 284 PubMed PMID: 22737721BLU 554, also known as Fisogatinib, CAS No. 1707289 21 1, CAS No. 1707289 21 1, is a fibroblast growth factor receptor 4 (FGFR4) inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma. BLU 554 demonstrates clinical benefit and tumor regression in patients with HCC with aberrant FGF19 expression. Product information CAS Number: 1707289 21 1 Molecular Weight: 503. 38 Formula: C24H24Cl2N4O4 Synonym: BLU 554 Fisogatinib