EXP3174 - CAS# 124750-92-1 Catalog No.:M6459-2 Oncol Lett

Oncol Lett

which can be significantly enhanced when combined with radiation

AKT and ERK prosurvival signaling

[Epub ahead of print] PubMed PMID: 24064905

oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency

EXP3174 - CAS# 124750-92-1 Catalog No.:M6459-2 Oncol LettEXP3174, also known as Losartan Carboxylic Acid, CAS No. 124750 92 1, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP3174 is a potent AT1 antagonist (Kis = 0. 57 and 0. 67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of