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CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 28(5):557-68

CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 28(5):557-68

Name: CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 28(5):557-68
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SKU: 36959146467
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SKU: 36959146467

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CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 28(5):557-68CB 5083, CAS No. 1542705 92 9, is a novel first in class, potent orally bio available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti tumor activity in solid and hematological models . CB 5083 causes rapid and sustained accumulation of poly ubiquitin in tumor xenografts after a single administration. CB 5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB 5083 appears to

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Description

28(5):557-68

8 nM and 5

392(2):77-80

selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM

Molecular Weight: 232

Exchange/Return Notes