INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg R59022 blocks entry of EBOV

R59022 blocks entry of EBOV pseudotypes in a concentration-dependent manner (IC50: ~5 µM)

Smiles: O=C(CC(C1C=CC=CC=1)C1C=CC=CC=1)N1CCN(CC1)C(C1C=CC=CC=1)C1C=CC=CC=1

Inflammation

as measured by decreased kynurenine levels (>50%) in plasma and dose dependent efficacy in mice bearing GM-CSF-secreting B16 melanoma tumors

A-803467 affects multiple biophysical characteristics of the canonical cardiac Nav1

INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg R59022 blocks entry of EBOVINCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5. 1 nM (hCCR2) and 9. 5 nM (mCCR2) in binding antagonism and 3. 8 nM (hCCR2) and 7. 8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100 fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target