SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 InChiKey: XQJWTJLJEYIUDZ-UHFFFAOYSA-N
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SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 InChiKey: XQJWTJLJEYIUDZ-UHFFFAOYSA-NSHP099, CAS No. 1801747 11 4, is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0. 07 M and p ERK modulation in cells IC50 = 0. 250 M. SHP099 exhibits dose dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays
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