BMS-690514 Catalog No.:M10884-2 1'-biphenyl]-4-yl]prop-2-enoic acid

1'-biphenyl]-4-yl]prop-2-enoic acid

small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity

Fe/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28

when comparing DM vs either ND or TR rats

Formula: C24H20Cl2FN5O2

BMS-690514 Catalog No.:M10884-2 1'-biphenyl]-4-yl]prop-2-enoic acidBMS 690514 is a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1 3. BMS 690514 is currently under investigation as an oral agent for the treatment of solid tumors. In vitro and in vivo studies were conducted to characterize the pharmacokinetics and metabolism. Through integration of in vitro and in vivo pharmacokinetic data and antitumor efficacy in nude