Lonafarnib - CAS# 193275-84-2 702 26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14

26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14

CAS Number: 511-28-4

H2O/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8

Metformin (500 μM) or AICAR strongly suppresses SREBP-1 mRNA expression in rat hepatocytes

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Lonafarnib - CAS# 193275-84-2 702 26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras