AHU-377 hemicalcium salt - CAS# 1369773-39-6 Catalog No.:M6489-2 PubMed PMID: 23030482

PubMed PMID: 23030482

Smiles: OC(=O)CCC1=CC=C(C=C1F)NCC1=CC=CC2=C1CCCN2CCOC1C=CC=CC=1

Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

resulting in increased energy expenditure

5)6)21-27-26-14(3)28(21)22/h7-10

AHU-377 hemicalcium salt - CAS# 1369773-39-6 Catalog No.:M6489-2 PubMed PMID: 23030482AHU 377 hemicalcium salt, CAS No. 1369773 39 6, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.