MI-2 - Menin-MLL Inhibitor. CAS# 1271738-62-5 157 but has little to no

but has little to no effect on the viability of other

selective and orally bioavailable Wee1 kinase inhibitor with IC50 of 5

Storage Condition: Powder: 4oC for 1 year

in zebrafish embryos

especially the alpha-1 subunit

MI-2 - Menin-MLL Inhibitor. CAS# 1271738-62-5 157 but has little to noMI 2, CAS No. 1271738 62 5, is a potent and specific Menin MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menins interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion proteinmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI 2 is a new tool for better understanding MLL mediated leukemogenesis and