PF-04449913 0077 InChi: InChI=1S/C19H28N2O4

InChi: InChI=1S/C19H28N2O4

prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner

tumor cell proliferation and invasion

Domitor hydrochloride

CAS Number: 487020-03-1

PF-04449913 0077 InChi: InChI=1S/C19H28N2O4Glasdegib, also known as PF 04449913, is an orally bioavailable small molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF 04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. Product