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PFI-2 Hydrochloride FKBP Degrader-3 Smiles: CCOC(=O)C1NC2=CC(Cl)=CC=C2C=1C(C(=O)NC(C)(C)C)N(CC1C=CC(Cl)=CC=1)C=O

PFI-2 Hydrochloride FKBP Degrader-3 Smiles: CCOC(=O)C1NC2=CC(Cl)=CC=C2C=1C(C(=O)NC(C)(C)C)N(CC1C=CC(Cl)=CC=1)C=O

Name: PFI-2 Hydrochloride FKBP Degrader-3 Smiles: CCOC(=O)C1NC2=CC(Cl)=CC=C2C=1C(C(=O)NC(C)(C)C)N(CC1C=CC(Cl)=CC=1)C=O
Brand: yutopean.com
SKU: 24264607827
Price: 122.00 USD
Availability: InStock
Rating: 4.6705000000000005 (11 reviews)

SKU: 24264607827

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PFI-2 Hydrochloride FKBP Degrader-3 Smiles: CCOC(=O)C1NC2=CC(Cl)=CC=C2C=1C(C(=O)NC(C)(C)C)N(CC1C=CC(Cl)=CC=1)C=OPFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an

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Smiles: CCOC(=O)C1NC2=CC(Cl)=CC=C2C=1C(C(=O)NC(C)(C)C)N(CC1C=CC(Cl)=CC=1)C=O

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