MK-5108 Size:Solid 10 mg Formula: C17H19ClN4O

Formula: C17H19ClN4O

(2013) Sci Transl Med

Augustine is a biochemical

InChi: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2

PubMed PMID: 25420519

MK-5108 Size:Solid 10 mg Formula: C17H19ClN4OMK 5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora A kinase. MK 5108 specifically inhibited Aurora A kinase in a panel of protein kinase assays. MK 5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK 5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK 5108 is currently tested in clinical trials