CNX-1351 - CAS# 1276105-89-5 mic Acid ZM-447439 selectively inhibits recombinant human

ZM-447439 selectively inhibits recombinant human Aurora A and B with IC50 values of 110 and 130 nM

2016 Jul 20

Transcriptomic profiling identified a gene program influenced by Tnv-6 that included autophagy-lysosomal pathway genes

wakefulness

1357302-64-7

CNX-1351 - CAS# 1276105-89-5 mic Acid ZM-447439 selectively inhibits recombinant humanCNX 1351 is a selective covalent Inhibitor of PI3K. In an end point assay, CNX 1351 potently inhibited PI3K and was 20400 times less potent against , , and . CNX 1351 inhibit PI3K signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX 1351 inhibits growth of cells dependent on PI3K. CNX 1351 also inhibits PI3K signaling in vivo and bonds to p110. Product information CAS Number: 1276105 89 5 Molecular