kobe2602 astin 01 mg/mL(0

01 mg/mL(0

(2013) Bioorg Med Chem

Gemfibrozil is a peroxisome proliferator receptor alpha agonist

Smiles: OC(=O)C1=CC2CCCC(=C(C=2C=C1)C1C=CC(=CC=1)O[C@@H]1CN(CCCF)CC1)C1=CC=C(Cl)C=C1Cl

InChi: InChI=1S/C21H27N3O2/c1-16-3-4-17(2)20(15-16)26-14-11-23-19-7-12-24(13-8-19)21(25)18-5-9-22-10-6-18/h3-6

kobe2602 astin 01 mg/mL(0Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibitory activity toward H Ras GTP c Raf 1 binding both in vivo and in vitro. Kobe2602 effectively inhibits both anchorage dependent and independent growth and induce apoptosis of H ras(G12V) transformed NIH 3T3 cells, which is accompanied by down regulation of downstream molecules such as MEK ERK, Akt, and RalA as well as an upstream molecule, Son of