4SC-202 free base Catalog No.:M8611-10 Apilimod inhibits the production of

Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis

25 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels

CAS Number: 328543-09-5

The thalidomide moiety drives proteasomal degradation

radiation alone

4SC-202 free base Catalog No.:M8611-10 Apilimod inhibits the production ofDomatinostat, also known as 4SC 202, is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC 202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor