Exatecan Mesylate - CAS# 169869-90-3 noprol InChi: InChI=1S/C35H49F2N7O4/c1-5-34(6-2

InChi: InChI=1S/C35H49F2N7O4/c1-5-34(6-2

Smiles: C/C=C1\NC(=O)[C@H]2CSSCCC=C[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC\1=O)C(C)C |t:12|

39(12):858-80

BMP signaling modulates hedgehog-induced secondary heart field proliferation

whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0

Exatecan Mesylate - CAS# 169869-90-3 noprol InChi: InChI=1S/C35H49F2N7O4/c1-5-34(6-2Exatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater