PAP-1 H 3-26 2011 Jan 21

2011 Jan 21

angiogenesis and survival

Chemical Name: N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-ylbenzamide

Smiles: NC1C=CN([C@@H]2CS[C@H](CO)O2)C(=O)N=1

3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5

PAP-1 H 3-26 2011 Jan 21SPS 4251, also known as AS 77 and PAP 1, is a KCNA3 (Potassium voltage gated channel, shaker related subfamily, member 3) channel blocker potentially for the treatment of plaque psoriasis. Kv1. 3 channels regulate the activation proliferation of effector memory T cells and thus play a critical role in the pathogenesis of autoimmune diseases. PAP 1 reduced the secretion of TNF by adipose tissue but had no effect on the secretion of IL 6. PAP 1 can also