AY 77 Size:10mg solid A Negative Allosteric Modulator of

A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist

4-dichlorobenzylidene)piperidin-4-one

selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM

Nathalie Schlienger

1-hi]indol-7-yl)-4-(imidazo[1

AY 77 Size:10mg solid A Negative Allosteric Modulator ofAY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1 2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 M for ERK1 2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro. Product information CAS Number: 1835734 92 3 Molecular Weight: 404. 50 Formula: C21H32N4O4 Synonym: AY77 AY 77 Isox Cha Chg NH2 Chemical Name: N ((S) 1 (((S) 2 amino 1 cyclohexyl 2