HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Three alternatively spliced transcript variants

Three alternatively spliced transcript variants encoding different isoforms have been found for PPP1CA

The different transcripts result from the use of alternate transcription initiation sites

including 2-5-oligoadenylate synthetase

part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human

Mutations in this gene result in pseudohypoaldosteronism type IIB

HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Three alternatively spliced transcript variantsContains two independent C terminal transactivation domains NTAD and CTAD which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID). Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes including erythropoietin glucose transporters glycolytic enzymes vascular endothelial growth factor and