MIB2 Polyclonal Antibody, 50ul Yeast Expression Transcript variants encoding different isoforms

Transcript variants encoding different isoforms have been identified for this gene

similarity:Belongs to the tubulin family

Mutations in SLC4A11 have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2

The TRIM motif includes three zinc-binding domains| namely a RING| a B-box type 1 and a B-box type 2| and a coiled-coil region

Also highly expressed in ovarian and leukemia cell lines

MIB2 Polyclonal Antibody, 50ul Yeast Expression Transcript variants encoding different isoformsE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result