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Rb Monoclonal Antibody, 50ul Bacterial Expression This cytokine is a ligand

SKU: 9497583932

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Rb Monoclonal Antibody, 50ul Bacterial Expression This cytokine is a ligandThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6

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This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins

Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II

E3 ubiquitin-protein ligase UHRF1binds to specific DNA sequences

Rb Monoclonal Antibody, 50ul Bacterial Expression This cytokine is a ligandThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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