Human Matrix Metalloproteinase-16, MMP16 ELISA Kit , 96T Sample Library Tubes May also play a role

May also play a role in neovascularization or angiogenesis

Isoform 2 may act as a repressor of NF-kappa-B and apoptosis

an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 12297508

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation

and thought to participate in the regulation of T-cell-mediated immune response

Human Matrix Metalloproteinase-16, MMP16 ELISA Kit , 96T Sample Library Tubes May also play a roleEndopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.