TIG1 Polyclonal Antibody, 100ul Immunoassays Mutations in ACVR1B are associated

Mutations in ACVR1B are associated with pituitary tumors

while the natural color allows for easy identification

The protein plays a role in pre-mRNA processing

which negatively regulates T-cell receptor (TCR) signaling

but mutations in this gene have not been associated with the disease

TIG1 Polyclonal Antibody, 100ul Immunoassays Mutations in ACVR1B are associatedThis gene was identified as a retinoid acid (RA) receptor responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.