Srb7 Polyclonal Antibody, 50ul Variant Libraries Alterations in this region have

Alterations in this region have been associated with the Beckwith-Wiedemann syndrome

Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

This gene is a member of the SPANX family of cancer/testis-associated genes| which are located in a cluster on chromosome X

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17

Srb7 Polyclonal Antibody, 50ul Variant Libraries Alterations in this region haveMED21 (mediator complex subunit 21) encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of MED21 is located on chromosome 8. Alternative splicing results in multiple transcript variants.