TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Phosphorylation promotes association of TFEB

Phosphorylation promotes association of TFEB with 14-3-3 family proteins and retention in the cytosol

which regulates its nuclear matrix and chromatin association

Mutations in this gene cause Hermansky-Pudlak syndrome 8

growth control

namely the Shaw subfamily

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Phosphorylation promotes association of TFEBCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only