NFKappaB-p65 Polyclonal Antibody, 100ul[BT-AP05989] Cell Transfection Alternatively spliced transcripts encoding different

Alternatively spliced transcripts encoding different isoforms have been identified for this gene

This gene has abundant and specific expression in the kidney

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The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus

Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis

NFKappaB-p65 Polyclonal Antibody, 100ul[BT-AP05989] Cell Transfection Alternatively spliced transcripts encoding differentNF kappa B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF kappa B moves to the nucleus and activates transcription of specific genes. NF kappa B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF kappa B is NFKB1 complexed with the product of RELA, RELA. Four