YAP(Phospho-Ser109) Rabbit Polyclonal Antibody, 100ul Immuno Plates Several alternatively spliced transcript variants

Several alternatively spliced transcript variants of this gene have been described

CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion

SLC39A1 encodes a member of the zinc-iron permease family

The coating on the surface is firm and convenient for daily experimental operation

this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion

YAP(Phospho-Ser109) Rabbit Polyclonal Antibody, 100ul Immuno Plates Several alternatively spliced transcript variantsThis gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development growth repair and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.