PLXB1 Polyclonal Antibody, 100ul Electrophoresis & Labeling The protein (ataxin 2) encoded

The protein (ataxin 2) encoded by ATXN2 has two globular domains near the N-terminus

Alterations in levels of the encoded protein may be associated with many diseases

Several transcript variants encoding different isoforms have been found for PPP1R12A

It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development

It seems to interact in a multiprotein complex with RbAp48 and HDAC3

PLXB1 Polyclonal Antibody, 100ul Electrophoresis & Labeling The protein (ataxin 2) encodeddisease: Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.,Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,PTM: Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.,PTM: