Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation Members of the Ikaros (ZNFN1A1

Members of the Ikaros (ZNFN1A1

This gene encodes a member of the G-protein coupled receptor family

CNKSR2 encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras

ERK and PI3K kinase/Akt

All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation Members of the Ikaros (ZNFN1A1Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.