EDA Polyclonal Antibody, 50ul Reagent Reservoirs in the chromosome 17q21 region

in the chromosome 17q21 region

This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

induction:In hepatoblastoma HepG2 cells

Mutations in this gene result in malonyl-CoA decarboyxlase deficiency

EDA Polyclonal Antibody, 50ul Reagent Reservoirs in the chromosome 17q21 regionThe protein encoded by EDA (ectodysplasin A) is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell cell signaling during the development of ectodermal organs. Defects in EDA are a cause of ectodermal dysplasia, anhidrotic, which is also known as X linked hypohidrotic ectodermal dysplasia. Several