Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration May play a role in

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function

This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs

The encoded protein serves as a ribosome release factor for this ribosome

MAP kinase p38 and JNK

This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis

Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit, 96T Filtration May play a role inCell surface receptor for the cytokine IL10 that participates in IL10 mediated anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed: 16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively