RHBT2 Rabbit Polyclonal Antibody, 50ul Cell Screening and Imaging Mutations in this gene result

Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes

This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion

It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas

Localizes to nucleolus during S phase

RHBT2 Rabbit Polyclonal Antibody, 50ul Cell Screening and Imaging Mutations in this gene resultThe protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin 3 protein a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.